Gene optimization


To cure genetic diseases by correcting the underlying genetic problem with optimized genes.

Thousands of diseases and conditions are the result of genetic mutations that either fail to produce proteins or make faulty proteins. Conventional treatment options address the symptoms or require repeat dosing. Gene replacement therapy offers curative solutions.

Gene replacement therapy requires better-than-wildtype performing genes to minimize dosing, maximize efficacy, and reduce immunogenicity. Existing gene therapies are not simultaneously optimized across all these dimensions. Furthermore, certain diseases require replacement of genes that are too large to fit into existing delivery technologies, rendering them inaccessible.

Evozyne Solution
Using our computational biology approach, we engineer transgenes with superior performance in activity, affinity, stability, and immunogenicity. In addition, Evozyne’s technology enables miniaturization of the gene cassette, unlocking cures for previously inaccessible diseases.