The underlying science
The science of evolution-based protein design
Our platform is based on 20+ years of fundamental research in how and why proteins are built the way they are through the process of evolution. Below we highlight several key papers in the development of evolutionarily consistent models for proteins, understanding the physics of protein folding, function and evolvability, and designing & building synthetic proteins.
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2020
Molecular latent space simulators
Chemical Science
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2020
Evolution-based enzyme design
Science
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2018
Computational design of hepatitis C virus immunogens
Physical Biology
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2016
Mapping membrane activity using machine learning
PNAS
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2016
Origins of allostery and evolvability
Cell
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2015
Evolvability of proteins
Cell
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2012
Spatial architecture of function and adaption
Nature
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2011
Hotspots for allosteric control
Molecular Systems Biology
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2009
Protein sectors
Cell
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2008
Engineering allosteric control
Science
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2005
Evolutionary information for specifying protein folds
Nature
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2005
Natural-like function in artificial proteins
Nature
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1999
Evolutionarily conserved pathways of energetic connectivity
Science