The underlying science
The science of evolution-based protein design
Our platform is based on 20+ years of fundamental research in how and why proteins are built the way they are through the process of evolution. Below we highlight several key papers in the development of evolutionarily consistent models for proteins, understanding the physics of protein folding, function and evolvability, and designing & building synthetic proteins.
2020
Molecular latent space simulators
Chemical Science
2020
Evolution-based enzyme design
Science
2018
Computational design of hepatitis C virus immunogens
Physical Biology
2016
Mapping membrane activity using machine learning
PNAS
2016
Origins of allostery and evolvability
Cell
2015
Evolvability of proteins
Cell
2012
Spatial architecture of function and adaption
Nature
2011
Hotspots for allosteric control
Molecular Systems Biology
2009
Protein sectors
Cell
2008
Engineering allosteric control
Science
2005
Evolutionary information for specifying protein folds
Nature
2005
Natural-like function in artificial proteins
Nature
1999
Evolutionarily conserved pathways of energetic connectivity
Science